Does CBD Have Any Side Effects?

Cannabidiol (CBD) has the potential for treating a wide array of health conditions. This cannabinoid, which is derived from the cannabis plant, has anti-oxidant, neuroprotective, anti-inflammatory, and anticonvulsant properties.

CBD is effective in treating cancer cells in-vitro. High doses of CBD can be used to treat various psychiatric disorders like dementia and schizophrenia. This cannabinoid is largely non-toxic. However, many people question if CBD has any side effects.


Cannabis has been used as natural medicine for thousands of years. The herb is rated as less dangerous substance than alcohol and nicotine in terms of toxicity.

CBD is non-psychoactive and has been shown to be generally safe. It acts on the CB1 and CB2 receptors of your endocannabinoid system indirectly. However, CBD also has some minor side effects.

CBD Side Effects

The most common side effects of CBD include tiredness, diarrhea, and losss of appetite.

Some side effects have also been observed in vitro. This means during experiments in a petri dish. These side effects include altered cell viability, reduced fertilization capacity, and inhibited liver drug metabolism.

Further research involving human participants is required to determine the full scope of side effects of CBD.

Liver Drug Metabolism

One side effect of CBD is its effect on drug metabolism within your liver. This is very important if you are taking other pharmaceutical medications. CBD interacts with drug-metabolizing enzymes. These enzymes are responsible for breaking down CBD as well. Certain pharmaceutical drugs inhibit these enzymes, while others ramp up levels of this enzyme. If you are taking other medications, you should consult your physician before you take CBD.

Movement Disorders

CBD can affect patients with dystonic movement disorder. In an experiment, CBD was administered to patients with this condition daily over a six-week period. Improvements in their movements were seen in all patients. However, some side effects included low blood pressure, psychomotor slowing, dry mouth, sedation, and lightheadedness. If the doses were over 300mg per day, the patients displayed increased hypokinesia and resting tremor.

Dry Mouth

Cannabis smokers are familiar with dry mouth. This usually occurs after smoking a joint. This can be easily remedied when you drink a glass of water or juice.

Cannabis decreases saliva secretion. This results in a dry mouth. The cannabinoid receptors of your endocannabinoid system exist within your salivary glands. CBD also interacts with these receptors. Thus, this causes the inhibition of your salivary secretion and induces dry mouth.


CBD is generally non-toxic and is unlikely to lead to a fatality. However, if you are taking high doses of this compound or if you have a medical condition, consult a doctor before using it.

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